Mouse monoclonal antibody Anti-Human PSMC5 | MyBioSource MBS120226 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human PSMC5

catalog :

MBS120226

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2837C4a

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120226

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human PSMC5

products short name :

PSMC5

products name syn :

Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5); S8; p45; SUG1; TBP10; TRIP1; p45/SUG

other names :

Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5), transcript variant 1, mRNA; 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; MSUG1 protein; Tat-binding protein homolog 10; proteasome 26S ATPase subunit 5; proteasome 26S subunit ATPase 5; proteasome subunit p45; thyroid hormone receptor-interacting protein 1; thyroid receptor interactor 1; proteasome (prosome, macropain) 26S subunit, ATPase, 5

products gene name :

PSMC5

other gene names :

PSMC5; PSMC5; S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG

uniprot entry name :

PRS8_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2837C4a

host :

Mouse

reactivity :

Human

sequence length :

1372

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. [NCBI Entrez Gene Summary]

ncbi gi num :

312596879

ncbi acc num :

NP_002796.4

ncbi gb acc num :

NM_002805

ncbi mol weight :

44,784 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway (1127621); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1127616); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1127617); APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (105833); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105831); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (105835); APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway (1127549); AUF1 (hnRNP D0) Destabilizes MRNA Pathway (187212); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1127620)

ncbi summary :

uniprot summary :

RPT6: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family. Protein type: Nuclear receptor co-regulator; Ubiquitin conjugating system; Proteasome complex. Chromosomal Location of Human Ortholog: 17q23.3. Cellular Component: nucleoplasm; proteasome complex; membrane; cytoplasm; proteasome regulatory particle; inclusion body; cytoplasmic vesicle; nucleus; cytosol. Molecular Function: thyrotropin-releasing hormone receptor binding; protein binding; TATA-binding protein binding; ATPase activity; transcription cofactor activity; transcription factor binding; ATP binding. Biological Process: transcription from RNA polymerase II promoter; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; positive regulation of transcription, DNA-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of programmed cell death; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; negative regulation of transcription, DNA-dependent; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage