Mouse monoclonal antibody Anti-Human E2F1 | MyBioSource MBS120216 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human E2F1

catalog :

MBS120216

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

658C2a

reactivity :

human

application :

immunocytochemistry

product information

catalog number :

MBS120216

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human E2F1

products short name :

E2F1

products name syn :

Homo sapiens E2F transcription factor 1; E2F-1; RBP3

other names :

Homo sapiens E2F transcription factor 1, mRNA; Transcription factor E2F1; transcription factor E2F1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; E2F transcription factor 1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1

products gene name :

E2F1

other gene names :

E2F1; E2F1; RBP3; E2F-1; RBAP1; RBBP3

uniprot entry name :

E2F1_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

658C2a

host :

Mouse

reactivity :

Human

sequence length :

2534

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [NCBI Entrez Gene Summary]

ncbi gi num :

34194582

ncbi acc num :

BC050369

ncbi mol weight :

46,920 Da

ncbi pathways :

Activation Of BH3-only Proteins Pathway (105658); Activation Of NOXA And Translocation To Mitochondria Pathway (105660); Activation Of PUMA And Translocation To Mitochondria Pathway (105661); Adipogenesis Pathway (198832); Apoptosis Pathway (105648); Assembly Of The Pre-replicative Complex Pathway (105821); Association Of Licensing Factors With The Pre-replicative Complex Pathway (105900); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); CDC6 Association With The ORC:origin Complex Pathway (105823)

ncbi summary :

uniprot summary :

E2F1: a member of the E2F/DP family of transcription factors.The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. Binds DNA cooperatively with Dp transcription factors in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.The Dp-1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. It can mediate both cell proliferation and p53-dependent apoptosis. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: nucleoplasm; Rb-E2F complex; cytoplasm; nucleus. Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity. Biological Process: Notch signaling pathway; transcription, DNA-dependent; apoptosis; positive regulation of transcription, DNA-dependent; mRNA stabilization; negative regulation of transcription from RNA polymerase II promoter; anoikis; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; DNA damage response, signal transduction resulting in induction of apoptosis; forebrain development; DNA damage checkpoint; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle

size1 :

0.1 mg

price1 :

345 USD