catalog number :
MBS120197
products full name :
Mouse monoclonal antibody Anti-Human TRIP13
products short name :
TRIP13
products name syn :
Homo sapiens thyroid hormone receptor interactor 13 (TRIP13); 16E1BP
other names :
Homo sapiens thyroid hormone receptor interactor 13 (TRIP13), transcript variant 1, mRNA; Pachytene checkpoint protein 2 homolog; pachytene checkpoint protein 2 homolog; 16E1-BP; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; TR-interacting protein 13; TRIP-13; human papillomavirus type 16 E1 protein-binding protein; thyroid receptor interacting protein 13; thyroid receptor-interacting protein 13; thyroid hormone receptor interactor 13; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13
products gene name :
TRIP13
other gene names :
TRIP13; TRIP13; 16E1BP
uniprot entry name :
PCH2_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Western Blot (WB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
ncbi acc num :
NP_004228.1
ncbi gb acc num :
NM_004237
ncbi mol weight :
22,084 Da
ncbi summary :
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
uniprot summary :
TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 5p15.33. Cellular Component: male germ cell nucleus; nucleus. Molecular Function: identical protein binding; protein binding; transcription cofactor activity; ATP binding. Biological Process: transcription from RNA polymerase II promoter; oogenesis; synaptonemal complex assembly; male meiosis I; double-strand break repair; meiotic recombination; spermatogenesis; oocyte maturation; spermatid development; female meiosis I