Mouse monoclonal antibody Anti-Human HIP2 | MyBioSource MBS120186 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human HIP2

catalog :

MBS120186

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

757C3a

reactivity :

human

application :

western blot, dot blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120186

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human HIP2

products short name :

HIP2

products name syn :

Homo sapiens huntingtin interacting protein 2 (HIP2); LIG;HYPG; UBE2K

other names :

Homo sapiens ubiquitin-conjugating enzyme E2K (UBE2K), transcript variant 1, mRNA; ubiquitin-conjugating enzyme E2 K; E2(25K); HIP-2; huntingtin interacting protein 2; huntingtin-interacting protein 2; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase; ubiquitin-conjugating enzyme E2K

products gene name :

HIP2

other gene names :

UBE2K; UBE2K; LIG; HIP2; HYPG; UBC1; E2-25K

uniprot entry name :

UBE2K_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

757C3a

host :

Mouse

reactivity :

Human

sequence length :

5259

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis. [NCBI Entrez Gene Summary]

ncbi gi num :

163660383

ncbi acc num :

NP_005330.1

ncbi gb acc num :

NM_005339

ncbi mol weight :

17,447 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Immune System Pathway (106386); Innate Immune System Pathway (106387); Negative Regulators Of RIG-I/MDA5 Signaling Pathway (187102); RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways (187097); Ubiquitin Mediated Proteolysis Pathway (83056); Ubiquitin Mediated Proteolysis Pathway (466)

ncbi summary :

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

UBE2K: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of Lys-48 -linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1. Interacts with RNF138/NARF. Interacts with BRCA1. By aggregated low-density lipoprotein. Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ligase; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19. Cellular Component: filopodium tip; intermediate filament cytoskeleton; cytoplasm; nucleus; actin cytoskeleton. Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; nucleotide binding; ATP binding; ligase activity. Biological Process: protein polyubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage