antibody

Mouse monoclonal antibody Anti-Human CHD3

MBS120180

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2172C1a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human CHD3

CHD3

Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3),?transcript variant 1, mRNA; ZFH; Mi-2a; Mi2-ALPHA

Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA; Chromodomain-helicase-DNA-binding protein 3; chromodomain-helicase-DNA-binding protein 3; ATP-dependent helicase CHD3; CHD-3; hZFH; mi-2 autoantigen 240 kDa protein; zinc finger helicase; zinc-finger helicase (Snf2-like); chromodomain helicase DNA binding protein 3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH

CHD3

CHD3; CHD3; ZFH; Mi-2a; Mi2-ALPHA

CHD3_HUMAN

Monoclonal

IgG1

2172C1a

Mouse

Human

7343

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [NCBI Entrez Gene Summary]

158420733

NP_001005273.1

NM_001005273

233,037 Da

Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); Gene Expression Pathway (105937); HDACs Deacetylate Histones Pathway (1127684); RNA Polymerase I Promoter Clearance Pathway (106551); RNA Polymerase I Transcription Pathway (106550); RNA Polymerase I Transcription Initiation Pathway (106553); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); Signaling Events Mediated By HDAC Class I Pathway (137997)

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

CHD-3 iso3: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts (via its C-terminal) with HABP4. Interacts with PCNT; the interaction regulates centrosome integrity. Widely expressed. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; EC 3.6.4.12; Helicase. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: nucleoplasm; centrosome; intermediate filament cytoskeleton; cytoplasm; nucleolus; NuRD complex; nucleus. Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; zinc ion binding; helicase activity; ATP binding. Biological Process: regulation of transcription from RNA polymerase II promoter; chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; centrosome organization and biogenesis; chromatin modification; spindle organization and biogenesis; DNA duplex unwinding

0.1 mg

345 USD