antibody

Mouse monoclonal antibody Anti-Human CCNF

MBS120179

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2123D1a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human CCNF

CCNF

Homo sapiens cyclin F (CCNF), mRNA; FBX1; FBXO1

Homo sapiens cyclin F (CCNF), mRNA; Cyclin-F; cyclin-F; F-box only protein 1; G2/mitotic-specific cyclin-F; cyclin F; F-box only protein 1

CCNF

CCNF; CCNF; FBX1; FBXO1

CCNF_HUMAN

Monoclonal

IgG1

2123D1a

Mouse

Human

4287

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [NCBI Entrez Gene Summary]

118572587

NP_001752.2

NM_001761

87,640 Da

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

CCNF: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: centriole; SCF ubiquitin ligase complex; nucleus. Molecular Function: protein binding. Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mitosis; re-entry into mitotic cell cycle; cell division; protein ubiquitination; placenta development

0.1 mg

345 USD