catalog number :
MBS120174
products full name :
Mouse monoclonal antibody Anti-Human LSM8
products short name :
LSM8
products name syn :
Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM8); YJR022W
other names :
Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM8), mRNA; U6 snRNA-associated Sm-like protein LSm8; LSM8 homolog, U6 small nuclear RNA associated; MAK31-like protein; N-alpha-acetyltransferase 38, NatC auxiliary subunit; U6 snRNA-associated Sm-like protein LSm8; LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
products gene name :
LSM8
other gene names :
LSM8; LSM8; LSM8; NAA38
uniprot entry name :
LSM8_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus. [NCBI Entrez Gene Summary]
ncbi acc num :
NP_057284.1
ncbi gb acc num :
NM_016200
ncbi mol weight :
10,403 Da
ncbi pathways :
Lsm 2-8 Complex Pathway (413461); Lsm 2-8 Complex Pathway (890612); RNA Degradation Pathway (117291); RNA Degradation Pathway (116127); Spliceosome Pathway (125136); Spliceosome Pathway (124832); Spliceosome, U4/U6.U5 Tri-snRNP Pathway (413445); Spliceosome, U4/U6.U5 Tri-snRNP Pathway (890601)
ncbi summary :
This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]
uniprot summary :
LSM8: Binds specifically to the 3 -terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. Protein type: RNA splicing. Chromosomal Location of Human Ortholog: 7q31.31. Cellular Component: spliceosome; U4/U6 x U5 tri-snRNP complex. Molecular Function: protein binding; U6 snRNA 3 -end binding; U6 snRNA binding. Biological Process: nuclear mRNA splicing, via spliceosome