catalog number :
MBS120165
products full name :
Mouse monoclonal antibody Anti-Human AXUD1
products short name :
AXUD1
products name syn :
Homo sapiens AXIN1 up-regulated 1 (AXUD1), mRNA; URAX1; TAIP-3;DKFZp566F164;FAM130B
other names :
Homo sapiens cysteine-serine-rich nuclear protein 1 (CSRNP1), mRNA; Cysteine/serine-rich nuclear protein 1; cysteine/serine-rich nuclear protein 1; AXIN1 up-regulated 1; TGF-beta induced apoptosis protein 3; TGF-beta-induced apoptosis protein 3; axin-1 up-regulated gene 1 protein; cysteine-serine-rich nuclear protein 1; Axin-1 up-regulated gene 1 protein; Protein URAX1; TGF-beta-induced apoptosis protein 3; TAIP-3
products gene name :
AXUD1
other gene names :
CSRNP1; CSRNP1; AXUD1; URAX1; TAIP-3; CSRNP-1; FAM130B
uniprot entry name :
CSRN1_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [NCBI Entrez Gene Summary]
ncbi acc num :
NP_149016.2
ncbi gb acc num :
NM_033027
ncbi mol weight :
63,508 Da
ncbi summary :
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008]
uniprot summary :
AXUD1: Binds to the consensus sequence 5 -AGAGTG-3 and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis. Belongs to the AXUD1 family. Chromosomal Location of Human Ortholog: 3p22. Cellular Component: nucleus. Molecular Function: sequence-specific DNA binding; transcription factor activity. Biological Process: transcription, DNA-dependent; apoptosis; skeletal morphogenesis; positive regulation of transcription from RNA polymerase II promoter; platelet-derived growth factor receptor signaling pathway; palate development; post-embryonic development