Mouse monoclonal antibody Anti-Human TWIST | MyBioSource MBS120163 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human TWIST

catalog :

MBS120163

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Twist2C1a

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120163

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human TWIST

products short name :

TWIST

products name syn :

Homo sapiens twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) (TWIST1); SCS;ACS3; BPES2; BPES3;TWIST1

other names :

Homo sapiens twist family bHLH transcription factor 1 (TWIST1), mRNA; Twist-related protein 1; twist-related protein 1; B-HLH DNA binding protein; H-twist; TWIST homolog of drosophila; class A basic helix-loop-helix protein 38; twist basic helix-loop-helix transcription factor 1; twist homolog 1; twist family bHLH transcription factor 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist

products gene name :

TWIST

other gene names :

TWIST1; TWIST1; CRS; CSO; SCS; ACS3; CRS1; BPES2; BPES3; TWIST; bHLHa38

uniprot entry name :

TWST1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

Twist2C1a

host :

Mouse

reactivity :

Human

sequence length :

1669

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [NCBI Entrez Gene Summary]

ncbi gi num :

68160957

ncbi acc num :

NP_000465.1

ncbi gb acc num :

NM_000474

ncbi mol weight :

20,954 Da

ncbi pathways :

Adipogenesis Pathway (198832); HIF-2-alpha Transcription Factor Network Pathway (137956); Neural Crest Differentiation Pathway (672460); Notch-mediated HES/HEY Network Pathway (169347); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054)

ncbi summary :

uniprot summary :

TWIST1: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Efficient DNA binding requires dimerization with another bHLH protein. Homodimer or heterodimer with E proteins such as TCF3. ID1 binds preferentially to TCF3 but does not interact efficiently with TWIST1 so ID1 levels control the amount of TCF3 available to dimerize with TWIST1 and thus determine the type of dimer formed. Subset of mesodermal cells. Protein type: Transcription regulation; Cell development/differentiation; Inhibitor; DNA-binding. Chromosomal Location of Human Ortholog: 7p21.2. Cellular Component: nucleus. Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; protein heterodimerization activity; bHLH transcription factor binding; transcription factor binding. Biological Process: embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; negative regulation of skeletal muscle development; muscle development; neuron migration; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; palate development; embryonic hindlimb morphogenesis; negative regulation of histone phosphorylation; negative regulation of histone acetylation; odontogenesis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of osteoblast differentiation; ossification; in utero embryonic development; negative regulation of transcription factor activity; outer ear morphogenesis; negative regulation of tumor necrosis factor production; embryonic cranial skeleton morphogenesis; positive regulation of tumor necrosis factor production; positive regulation of fatty acid beta-oxidation; osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; regulation of bone mineralization; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of phosphoinositide 3-kinase cascade. Disease: Robinow-sorauf Syndrome; Craniosynostosis 1; Saethre-chotzen Syndrome

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage