catalog number :
MBS120146
products full name :
Mouse monoclonal antibody Anti-Human CHD1L
products short name :
CHD1L
products name syn :
Homo sapiens chromodomain helicase DNA binding protein 1-like (CHD1L); ALC1; CHDL; FLJ22530
other names :
Homo sapiens chromodomain helicase DNA binding protein 1-like (CHD1L), transcript variant 1, mRNA; Chromodomain-helicase-DNA-binding protein 1-like; chromodomain-helicase-DNA-binding protein 1-like; amplified in liver cancer 1; amplified in liver cancer protein 1; chromodomain helicase DNA binding protein 1-like; Amplified in liver cancer protein 1
products gene name :
CHD1L
other gene names :
CHD1L; CHD1L; ALC1; CHDL
uniprot entry name :
CHD1L_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
ncbi acc num :
NP_004275.4
ncbi gb acc num :
NM_004284
ncbi mol weight :
69,139 Da
ncbi summary :
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]
uniprot summary :
CHD1L: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; EC 3.6.4.12; Helicase. Chromosomal Location of Human Ortholog: 1q12. Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus. Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATPase activity; nucleotide binding; ATP binding. Biological Process: chromatin remodeling; DNA repair; response to DNA damage stimulus; DNA duplex unwinding