Mouse monoclonal antibody Anti-Human ASH2L | MyBioSource MBS120142 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human ASH2L

catalog :

MBS120142

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2046D2a

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120142

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human ASH2L

products short name :

ASH2L

products name syn :

Homo sapiens ash2 (absent, small, or homeotic)-like (Drosophila) (ASH2L); ASH2; ASH2L1; ASH2L2

other names :

Homo sapiens ash2 (absent, small, or homeotic)-like (Drosophila) (ASH2L), transcript variant 1, mRNA; Set1/Ash2 histone methyltransferase complex subunit ASH2; set1/Ash2 histone methyltransferase complex subunit ASH2; ASH2-like protein; ash2 (absent, small, or homeotic)-like (Drosophila); ASH2-like protein

products gene name :

ASH2L

other gene names :

ASH2L; ASH2L; ASH2; Bre2; ASH2L1; ASH2L2

uniprot entry name :

ASH2L_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2046D2a

host :

Mouse

reactivity :

Human

sequence length :

2954

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. May function as a transcriptional regulator. May play a role in hematopoiesis. [UniProtKB Function]

ncbi gi num :

387864277

ncbi acc num :

NP_004665.2

ncbi gb acc num :

NM_004674

ncbi mol weight :

60,208 Da

ncbi pathways :

Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); Disease Pathway (530764); PKMTs Methylate Histone Lysines Pathway (1127686); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1127632); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516); XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway (1127633)

uniprot summary :

ASH2L: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A and SETD1B. Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription regulation; Methyltransferase. Chromosomal Location of Human Ortholog: 8p11.2. Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus. Molecular Function: protein binding; DNA binding; histone lysine N-methyltransferase activity (H3-K4 specific); metal ion binding. Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to estrogen stimulus; positive regulation of cell proliferation; histone H3-K4 methylation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage