Recombinant Human 3-phosphoinositide-dependent protein kinase 1 (PDPK1) | MyBioSource MBS1201397 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

catalog :

MBS1201397

quantity :

0.5 mg (E-Coli)

price :

1350 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1201397

products type :

Recombinant Protein

products full name :

Recombinant Human 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

products short name :

3-phosphoinositide-dependent protein kinase 1 (PDPK1)

products name syn :

3-phosphoinositide-dependent protein kinase 1; hPDK1; EC=2.7.11.1

other names :

3-phosphoinositide-dependent protein kinase 1 isoform 3; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 1; PkB kinase like gene 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide dependent protein kinase 1

products gene name :

PDPK1

products gene name syn :

PDPK1; PDK1

other gene names :

PDPK1; PDPK1; PDK1; PDPK2; PRO0461; PDK1; hPDK1

uniprot entry name :

PDPK1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-556

sequence length :

556

sequence :

MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ EVWRQRYQSH PDAAVQ

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

PDPK1; PDK1

ncbi gi num :

387849239

ncbi acc num :

NP_001248745.1

ncbi gb acc num :

NM_001261816.1

uniprot acc num :

O15530

ncbi mol weight :

50,838 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of PKB Pathway (106436); Adaptive Immune System Pathway (366160); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); B Cell Receptor Signaling Pathway (198909); BCR Signaling Pathway (138058); BDNF Signaling Pathway (712093); CD28 Co-stimulation Pathway (119553); CD28 Dependent PI3K/Akt Signaling Pathway (119554)

uniprot summary :

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Nuclear receptor co-regulator; Kinase, protein; Protein kinase, AGC; AGC group; PKB family. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: nucleoplasm; focal adhesion; cell projection; membrane; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; kinase activity; protein kinase binding; insulin receptor binding; ATP binding; phospholipase activator activity. Biological Process: regulation of mast cell degranulation; focal adhesion formation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; T cell receptor signaling pathway; protein amino acid phosphorylation; synaptic transmission; regulation of transcription, DNA-dependent; regulation of I-kappaB kinase/NF-kappaB cascade; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; activation of protein kinase B; calcium-mediated signaling; peptidyl-threonine phosphorylation; hyperosmotic response; cellular response to insulin stimulus; T cell costimulation; insulin receptor signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis

size1 :

0.5 mg (E-Coli)

price1 :

1350 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1350

size3 :

0.5 mg (Yeast)

price3 :

1570

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1570

size5 :

1 mg (E-Coli)

price5 :

2240

more info or order :

MyBioSource product webpage