antibody

Mouse monoclonal antibody Anti-Human TAF6

MBS120136

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

585D4a

western blot, immunocytochemistry, immunoprecipitation

Antibody

Mouse monoclonal antibody Anti-Human TAF6

TAF6

Homo sapiens TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa (TAF6), transcript variant 1; TAF2E; TAFII70;TAFII80; TAFII85; MGC:8964; DKFZp781E21155

Homo sapiens TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa (TAF6), transcript variant 1, mRNA; Transcription initiation factor TFIID subunit 6; transcription initiation factor TFIID subunit 6; RNA polymerase II TBP-associated factor subunit E; TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD; transcription initiation factor TFIID 70 kDa subunit; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80

TAF6

TAF6; TAF6; TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80

TAF6_HUMAN

Monoclonal

IgG1

585D4a

Mouse

Human

2787

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. [NCBI Entrez Gene Summary]

298676521

NP_005632.1

NM_005641

76,995 Da

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Disease Pathway (530764); Eukaryotic Transcription Initiation Pathway (198917); Gene Expression Pathway (105937); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984); HIV Transcription Initiation Pathway (105998); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865)

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

TAF6: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Belongs to the TAF6 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription initiation complex. Chromosomal Location of Human Ortholog: 7q22.1. Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleus. Molecular Function: protein binding; DNA binding; protein heterodimerization activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of cell proliferation; viral reproduction; regulation of transcription factor activity; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; transcription initiation; gene expression; negative regulation of cell cycle

0.1 mg

345 USD