antibody

Mouse monoclonal antibody Anti-Human YEATS4

MBS120135

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

YEATB1A8

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human YEATS4

YEATS4

Homo sapiens YEATS domain containing 4 (YEATS4); YAF9; GAS41;NUBI-1; 4930573H17Rik; B230215M10Rik

Homo sapiens YEATS domain containing 4 (YEATS4), transcript variant 1, mRNA; YEATS domain-containing protein 4; YEATS domain-containing protein 4; NuMA binding protein 1; glioma-amplified sequence 41; glioma-amplified sequence-41; nuBI1; nuMA-binding protein 1; YEATS domain containing 4; Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1

YEATS4

YEATS4; YEATS4; YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik

YETS4_HUMAN

Monoclonal

IgG1

YEATB1A8

Mouse

Human

1509

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [NCBI Entrez Gene Summary]

665821255

NP_006521.1

NM_006530

26,499 Da

C-MYB Transcription Factor Network Pathway (138073); Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); HATs Acetylate Histones Pathway (1127683)

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 12q13-q15. Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus. Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity. Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription, DNA-dependent

0.1 mg

345 USD