catalog number :
MBS120131
products full name :
Mouse monoclonal antibody Anti-Human ARID2
products short name :
ARID2
products name syn :
Homo sapiens AT rich interactive domain 2 (ARID, RFX-like) (ARID2); p200; BAF200; FLJ30619; KIAA1557; DKFZp686G052;DKFZp779P0222
other names :
Homo sapiens AT rich interactive domain 2 (ARID, RFX-like) (ARID2), mRNA; AT-rich interactive domain-containing protein 2; AT-rich interactive domain-containing protein 2; ARID domain-containing protein 2; BRG1-associated factor 200; zinc finger protein with activation potential; zipzap; zipzap/p200; AT rich interactive domain 2 (ARID, RFX-like); BRG1-associated factor 200; BAF200; Zinc finger protein with activation potential; Zipzap/p200
products gene name :
ARID2
other gene names :
ARID2; ARID2; p200; BAF200
uniprot entry name :
ARID2_HUMAN
form :
Mouse monoclonal anti-human ARID2 antibody in PBS (3.0 mM KCl, 1.5 mM KH PO , 140 mM NaCl, 8.0 mM Na HPO (pH 7.4)) containing 1% bovine serum albumin (BSA)and 0.05% sodium azide (NaN ).
concentration :
100 ug/ml (1.0 ml)
storage stability :
Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)
app notes :
WB:02-2ug/ml. ICC: 2-100ug/ml
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. Disposal: This antibody solution contains sodium azide (NaN )as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. [UniProtKB Function]
ncbi acc num :
NP_689854.2
ncbi gb acc num :
NM_152641
ncbi mol weight :
197 kDa
ncbi pathways :
Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); RMTs Methylate Histone Arginines Pathway (1127687)
ncbi summary :
ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]
uniprot summary :
ARID2: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. 3 isoforms of the human protein are produced by alternative splicing. Protein type: C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 12q12. Cellular Component: nucleoplasm; plasma membrane. Molecular Function: protein binding; DNA binding; metal ion binding. Biological Process: nucleosome disassembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification