antibody

Mouse monoclonal antibody Anti-Human ACIN1

MBS120125

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2005C3a

western blot, immunocytochemistry

Antibody

Mouse monoclonal antibody Anti-Human ACIN1

ACIN1

Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), mRNA; ACN; ACINUS; KIAA0670; DKFZp667N107

Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 1, mRNA; Apoptotic chromatin condensation inducer in the nucleus; apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152; apoptotic chromatin condensation inducer 1

ACIN1

ACIN1; ACIN1; ACN; ACINUS; fSAP152

ACINU_HUMAN

Monoclonal

IgG1

2005C3a

Mouse

Human

4951

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Induces apoptotic chromatin condensation after activation by CASP3. [UniProtKB Function]

190341058

NP_055792.1

NM_014977

150,557 Da

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Exon Junction Complex (EJC) Pathway (470353); Exon Junction Complex (EJC) Pathway (890638); Programmed Cell Death Pathway (1127510); RNA Transport Pathway (177876); RNA Transport Pathway (175229); Spliceosome Pathway (125136); Spliceosome Pathway (124832)

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described. Protein type: Spliceosome; RNA splicing; Apoptosis; RNA-binding. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleolus; nuclear speck; cytosol; nucleus. Molecular Function: protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding. Biological Process: positive regulation of monocyte differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of apoptosis; apoptosis; RNA splicing; erythrocyte differentiation; apoptotic chromosome condensation; mRNA processing; cell structure disassembly during apoptosis

0.1 mg

345 USD