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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human JARID1B
catalog :
MBS120120
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JARIA3D4
reactivity :
human
application :
western blot, dot blot
more info or order :
product information
catalog number :
MBS120120
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human JARID1B
products short name :
JARID1B
products name syn :
Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B); PUT1; PLU-1; FLJ10538; FLJ12459;FLJ12491; FLJ16281; FLJ23670; RBBP2H1A
other names :
Homo sapiens lysine (K)-specific demethylase 5B (KDM5B), mRNA; Lysine-specific demethylase 5B; lysine-specific demethylase 5B; RBP2-H1; cancer/testis antigen 31; histone demethylase JARID1B; jumonji, AT rich interactive domain 1B; jumonji/ARID domain-containing protein 1B; protein phosphatase 1, regulatory subunit 98; putative DNA/chromatin binding motif; retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A; lysine (K)-specific demethylase 5B; Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1
products gene name :
JARID1B
other gene names :
KDM5B; KDM5B; CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBBP2H1A
uniprot entry name :
KDM5B_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
JARIA3D4
host :
Mouse
reactivity :
Human
sequence length :
6393
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. [UniProtKB Function]
ncbi gi num :
57242795
ncbi acc num :
NP_006609.3
ncbi gb acc num :
NM_006618
ncbi mol weight :
179,409 Da
ncbi pathways :
Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); HDMs Demethylate Histones Pathway (1127685)
uniprot summary :
JARID1B: Histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9 or H3 Lys-27 . Demethylates trimethylated, dimethylated and monomethylated H3 Lys-4 . Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor; Demethylase; Oxidoreductase; EC 1.14.11.-; Cancer Testis Antigen (CTA). Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: protein binding; DNA binding; zinc ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; transcription corepressor activity; transcription factor activity. Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent
size1 :
0.1 mg
price1 :
345 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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