catalog number :
MBS120118
products full name :
Mouse monoclonal antibody Anti-Human CCNT2
products short name :
CCNT2
products name syn :
Homo sapiens cyclin T2 (CCNT2), transcript variant b, mRNA; FLJ90560; MGC134840
other names :
Homo sapiens cyclin T2 (CCNT2), transcript variant b, mRNA; Cyclin-T2; cyclin-T2; SDS-stable vimentin-bound DNA fragment HEF42VIM22; cyclin T2a; cyclin T2b; subunit of positive elongation transcription factor b; cyclin T2
products gene name :
CCNT2
other gene names :
CCNT2; CCNT2; CYCT2
uniprot entry name :
CCNT2_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Western Blot (WB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described. [NCBI Entrez Gene Summary]
ncbi acc num :
NP_490595.1
ncbi gb acc num :
NM_058241
ncbi mol weight :
73,682 Da
ncbi pathways :
Disease Pathway 530764!!Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway 161052!!Formation Of RNA Pol II Elongation Complex Pathway 105950!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!HIV Infection Pathway 105983!!HIV Life Cycle Pathway 105984!!HIV Elongation Arrest And Recovery Pathway 161051!!Late Phase Of HIV Life Cycle Pathway 105995!!Loss Of Function Of SMAD2/3 In Cancer Pathway 906019
ncbi summary :
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]