antibody

Mouse monoclonal antibody Anti-Human CARD8

MBS120117

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2108C2a

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS

Antibody

Mouse monoclonal antibody Anti-Human CARD8

CARD8

Homo sapiens caspase recruitment domain family, member 8 (CARD8); DACAR; NDPP1; TUCAN; CARDINAL; KIAA0955;MGC57162; DKFZp779L0366

Homo sapiens caspase recruitment domain family, member 8 (CARD8), transcript variant 2, mRNA; Caspase recruitment domain-containing protein 8; caspase recruitment domain-containing protein 8; CARD inhibitor of NF-kappaB-activating ligands; apoptotic protein NDPP1; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine; caspase recruitment domain family, member 8; Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCAN

CARD8

CARD8; CARD8; NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL

CARD8_HUMAN

Monoclonal

IgG1

2108C2a

Mouse

Human

5349

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB; see MIM 164011) in the context of apoptosis or inflammation, respectively (Bouchier-Hayes et al., 2001).[supplied by OMIM]. [NCBI Entrez Gene Summary]

296531358

NP_055774.2

NM_014959

60,652 Da

NOD Pathway (198792); NOD-like Receptor Signaling Pathway (122191); NOD-like Receptor Signaling Pathway (122131)

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

CARD8: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Inhibitor. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: protein binding; NACHT domain binding; protein homodimerization activity; caspase activator activity. Biological Process: caspase activation; positive regulation of caspase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion

0.1 mg

345 USD