antibody

Mouse monoclonal antibody Anti-Human BRD3

MBS120113

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2088C3a

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS

Antibody

Mouse monoclonal antibody Anti-Human BRD3

BRD3

Homo sapiens bromodomain containing 3 (BRD3), mRNA; ORFX; RING3L; KIAA0043

Homo sapiens bromodomain containing 3 (BRD3), mRNA; Bromodomain-containing protein 3; bromodomain-containing protein 3; RING3-like protein; bromodomain-containing 3; bromodomain containing 3; RING3-like protein

BRD3

BRD3; BRD3; ORFX; RING3L

BRD3_HUMAN

Monoclonal

IgG1

2088C3a

Mouse

Human

5673

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [NCBI Entrez Gene Summary]

207028804

NP_031397.1

NM_007371

60,942 Da

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

BRD3: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1 gene. A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, atypical; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BRD family. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: nucleus. Molecular Function: protein binding; chromatin binding. Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; chromatin modification

0.1 mg

345 USD