catalog number :
MBS120101
products full name :
Mouse monoclonal antibody Anti-Human DBF4
products short name :
DBF4
products name syn :
Homo sapiens DBF4 homolog (S. cerevisiae) (DBF4), mRNA; ASK; DBF4A
other names :
Homo sapiens DBF4 zinc finger (DBF4), mRNA; Protein DBF4 homolog A; protein DBF4 homolog A; DBF4 zinc finger A; DBF4-type zinc finger-containing protein 1; activator of S phase kinase; chiffon homolog A; zinc finger, DBF-type containing 1; DBF4 zinc finger; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1
products gene name :
DBF4
other gene names :
DBF4; DBF4; ASK; CHIF; DBF4A; ZDBF1
uniprot entry name :
DBF4A_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
Play a role as a regulatory subunit for CDC7 which activates its kinase activity. Is required for entry into S phase. The complex CDC7-DBF4 selectively phosphorylates MCM2 subunit of chromatin-associated MCM complex and then is involved in regulating the initiation of DNA replication during cell cycle{EC1,EC2}. [UniProtKB Function]
ncbi acc num :
NP_006707.1
ncbi gb acc num :
NM_006716
ncbi mol weight :
26,124 Da
ncbi pathways :
Activation Of ATR In Response To Replication Stress Pathway (105754); Activation Of The Pre-replicative Complex Pathway (105777); Cell Cycle Pathway (530733); Cell Cycle Checkpoints Pathway (105739); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); DNA Replication Pathway (198771); DNA Replication Pathway (105897)
uniprot summary :
DBF4: DBF4. Protein type: Protein kinase, regulatory subunit; Cell cycle regulation. Chromosomal Location of Human Ortholog: 7q21.3. Cellular Component: nucleoplasm. Molecular Function: nucleic acid binding; zinc ion binding; enzyme activator activity. Biological Process: positive regulation of catalytic activity; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle