Mouse monoclonal antibody Anti-Human TFAP2A | MyBioSource MBS120100 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human TFAP2A

catalog :

MBS120100

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

959C2a

reactivity :

human

application :

western blot, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120100

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human TFAP2A

products short name :

TFAP2A

products name syn :

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); AP-2; AP2TF; TFAP2; AP-2alpha

other names :

Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 1, mRNA; Transcription factor AP-2-alpha; transcription factor AP-2-alpha; AP-2 transcription factor; AP2-alpha; activating enhancer-binding protein 2-alpha; activator protein 2; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2

products gene name :

TFAP2A

other gene names :

TFAP2A; TFAP2A; AP-2; BOFS; AP2TF; TFAP2; AP-2alpha

uniprot entry name :

AP2A_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

959C2a

host :

Mouse

reactivity :

Human

sequence length :

3300

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Western Blot (WB), Flow Cytometry (FC/FACS)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM] [NCBI Entrez Gene Summary]

ncbi gi num :

109389359

ncbi acc num :

NP_003211.1

ncbi gb acc num :

NM_003220

ncbi mol weight :

47,440 Da

ncbi pathways :

Caspase Cascade In Apoptosis Pathway (137974); Corticotropin-releasing Hormone Pathway (920957); Neural Crest Differentiation Pathway (672460); Wnt Signaling Pathway NetPath (198799)

ncbi summary :

The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

uniprot summary :

AP-2 alpha: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5 -GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A- transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Belongs to the AP-2 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 6p24. Cellular Component: nucleoplasm; Golgi apparatus; centrosome; intracellular membrane-bound organelle; cytoplasm; nucleus. Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; chromatin binding. Biological Process: embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; negative regulation of epidermal growth factor receptor signaling pathway; neural crest cell development; regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; negative regulation of cell proliferation; sympathetic nervous system development; sensory perception of sound; oculomotor nerve formation; positive regulation of neuron apoptosis; epidermis morphogenesis; regulation of cell differentiation; negative regulation of neuron apoptosis; kidney development; trigeminal nerve development; inner ear morphogenesis; anterior neuropore closure; embryonic cranial skeleton morphogenesis; positive regulation of bone mineralization; embryonic body morphogenesis; forebrain neuron development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of cell migration. Disease: Branchiooculofacial Syndrome

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage