antibody

Mouse monoclonal antibody Anti-Human GTF2H2

MBS120088

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

GTF2F6A10

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human GTF2H2

GTF2H2

Homo sapiens general transcription factor IIH, polypeptide 2, 44kDa, mRNA (cDNA clone IMAGE:3932186), complete cds; BTF2; TFIIH; BTF2P44; T-BTF2P44

Homo sapiens general transcription factor IIH, polypeptide 2, 44kDa, mRNA; General transcription factor IIH subunit 2; general transcription factor IIH subunit 2; BTF2 p44; TFIIH basal transcription factor complex p44 subunit; basic transcription factor 2 44 kDa subunit; general transcription factor IIH polypeptide 2; general transcription factor IIH, polypeptide 2, 44kD subunit; general transcription factor IIH, polypeptide 2, 44kDa; Basic transcription factor 2 44 kDa subunit; BTF2 p44; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit

GTF2H2

GTF2H2; GTF2H2; p44; BTF2; TFIIH; BTF2P44; T-BTF2P44

TF2H2_HUMAN

Monoclonal

IgG1

GTF2F6A10

Mouse

Human

860

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [NCBI Entrez Gene Summary]

13529148

BC005345

44,419 Da

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); DNA Repair Pathway (105837); Disease Pathway (530764); Dual Incision Reaction In GG-NER Pathway (105887); Dual Incision Reaction In TC-NER Pathway (105892); Epigenetic Regulation Of Gene Expression Pathway (1127671); Eukaryotic Transcription Initiation Pathway (198917); Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway (161052); Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway (106004)

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008]

GTF2H2: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter. Belongs to the GTF2H2 family. 1 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin conjugating system; Ubiquitin ligase; DNA repair, damage; Transcription factor. Chromosomal Location of Human Ortholog: 5q13.2. Cellular Component: nucleoplasm; holo TFIIH complex. Molecular Function: RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; nucleic acid binding; zinc ion binding; translation factor activity, nucleic acid binding; protein N-terminus binding; transcription factor activity; protein kinase activity. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; translation; positive regulation of viral transcription; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; regulation of gene expression, epigenetic; protein amino acid phosphorylation; mRNA capping; regulation of transcription, DNA-dependent; G-protein coupled receptor internalization; negative regulation of gene expression, epigenetic; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; nucleotide-excision repair, DNA damage removal; gene expression; transcription initiation from RNA polymerase I promoter; response to UV

0.1 mg

345 USD