Mouse monoclonal antibody Anti-Human TAF15 | MyBioSource MBS120082 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human TAF15

catalog :

MBS120082

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TAF15B11A6

reactivity :

human

application :

immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120082

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human TAF15

products short name :

TAF15

products name syn :

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; TAFII68; RBP56; TAF2N; hTAFII68

other names :

Homo sapiens TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, mRNA; TATA-binding protein-associated factor 2N; TATA-binding protein-associated factor 2N; RBP56/CSMF fusion; TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56); TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TBP-associated factor 15; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; 68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56

products gene name :

TAF15

other gene names :

TAF15; TAF15; Npl3; RBP56; TAF2N; TAFII68

uniprot entry name :

RBP56_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

TAF15B11A6

host :

Mouse

reactivity :

Human

sequence length :

2188

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified. [NCBI Entrez Gene Summary]

ncbi gi num :

28279784

ncbi acc num :

BC046099

ncbi mol weight :

61,558 Da

ncbi pathways :

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

uniprot summary :

TAF15: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; Oncoprotein; Translation. Chromosomal Location of Human Ortholog: 17q11.1-q11.2. Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus. Molecular Function: protein binding; DNA binding; zinc ion binding; nucleotide binding. Biological Process: positive regulation of transcription, DNA-dependent. Disease: Chondrosarcoma, Extraskeletal Myxoid

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage