Mouse monoclonal antibody Anti-Human NR4A1 | MyBioSource MBS120078 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human NR4A1

catalog :

MBS120078

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NR4AB9G12

reactivity :

human

application :

immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120078

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human NR4A1

products short name :

NR4A1

products name syn :

Homo sapiens nuclear receptor subfamily 4, group A, member 1 (NR4A1), transcript variant 1, mRNA; HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB

other names :

Homo sapiens nuclear receptor subfamily 4, group A, member 1 (NR4A1), transcript variant 1, mRNA; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4 group A member 1; ST-59; TR3 orphan receptor; early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; nerve growth factor IB nuclear receptor variant 1; nuclear hormone receptor NUR/77; orphan nuclear receptor HMR; orphan nuclear receptor TR3; steroid receptor TR3; testicular receptor 3; nuclear receptor subfamily 4, group A, member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3

products gene name :

NR4A1

other gene names :

NR4A1; NR4A1; HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77

uniprot entry name :

NR4A1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

NR4AB9G12

host :

Mouse

reactivity :

Human

sequence length :

2692

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this gene. [NCBI Entrez Gene Summary]

ncbi gi num :

320202953

ncbi acc num :

NP_002126.2

ncbi gb acc num :

NM_002135

ncbi mol weight :

33,754 Da

ncbi pathways :

AKT Phosphorylates Targets In The Nucleus Pathway (106476); Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); Corticotropin-releasing Hormone Pathway (920957); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR Pathway (160957)

ncbi summary :

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

Nur77: an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5 -AAAAGGTCA-3 . May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Protein type: Apoptosis; Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleus. Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity. Biological Process: epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; cell migration during sprouting angiogenesis; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage