catalog number :
MBS120076
products full name :
Mouse monoclonal antibody Anti-Human CIB2
products short name :
CIB2
products name syn :
Homo sapiens calcium and integrin binding family member 2, mRNA (cDNA clone MGC:48487 IMAGE:5287072), complete cds; KIP2
other names :
Homo sapiens calcium and integrin binding family member 2, mRNA; Calcium and integrin-binding family member 2; calcium and integrin-binding family member 2; DNA-dependent protein kinase catalytic subunit-interacting protein 2; calcium and integrin binding family member 2; Kinase-interacting protein 2; KIP 2
products gene name :
CIB2
other gene names :
CIB2; CIB2; KIP2; USH1J; DFNB48
uniprot entry name :
CIB2_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
The amino acid sequence the protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a Ca2+-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs). [NCBI Entrez Gene Summary]
ncbi mol weight :
15,816 Da
ncbi summary :
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 15q24. Cellular Component: muscle tendon junction; photoreceptor inner segment; neuromuscular junction; sarcolemma. Molecular Function: integrin binding; protein binding; calcium ion binding. Biological Process: calcium ion homeostasis; photoreceptor cell maintenance. Disease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij