antibody

Mouse monoclonal antibody Anti-Human PAX8

MBS120074

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

PAX8R1

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS

Antibody

Mouse monoclonal antibody Anti-Human PAX8

PAX8

paired box gene 8

Homo sapiens paired box 8, mRNA; Paired box protein Pax-8; paired box protein Pax-8; paired domain gene 8; paired box 8

PAX8

PAX8; PAX8

PAX8_HUMAN

Monoclonal

IgG1

PAX8R1

Mouse

Human

2698

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [NCBI Entrez Gene Summary]

33987990

BC001060

31,044 Da

Id Signaling Pathway (198871); Pathways In Cancer (83105); TSH Signaling Pathway (672446); Thyroid Cancer Pathway (83112); Thyroid Cancer Pathway (524); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 2q13. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity. Biological Process: regulation of apoptosis; inner ear morphogenesis; anatomical structure morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; pronephros development; urogenital system development. Disease: Hypothyroidism, Congenital, Nongoitrous, 2

0.1 mg

345 USD