catalog number :
MBS120058
products full name :
Mouse monoclonal antibody Anti-Human MGA
products short name :
MGA
products name syn :
MAX gene associated; KIAA0518; MAD5; MXD5; FLJ12634
other names :
Homo sapiens MAX gene associated, mRNA; MAX gene-associated protein; MAX gene-associated protein; MAX dimerization protein 5; MGA, MAX dimerization protein; MAX dimerization protein 5
other gene names :
MGA; MGA; MAD5; MXD5
uniprot entry name :
MGAP_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
ncbi mol weight :
336,159 Da
uniprot summary :
MGA iso6: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5 -AATTTCACACCTAGGTGTGAAATT-3 core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor; DNA-binding. Chromosomal Location of Human Ortholog: 15q14. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm. Molecular Function: protein dimerization activity; DNA binding; transcription factor activity. Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent