catalog number :
MBS120057
products full name :
Mouse monoclonal antibody Anti-Human ARID3A
products short name :
ARID3A
products name syn :
AT rich interactive domain 3A (BRIGHT- like); BRIGHT; E2FBP1; DRIL3
other names :
Homo sapiens AT rich interactive domain 3A (BRIGHT-like), mRNA; AT-rich interactive domain-containing protein 3A; AT-rich interactive domain-containing protein 3A; ARID domain-containing 3A; ARID domain-containing protein 3A; AT rich interactive domain 3A (BRIGHT- like) protein; B-cell regulator of IgH transcription; E2F-binding protein 1; dead ringer-like 1; dead ringer-like protein 1; AT rich interactive domain 3A (BRIGHT-like); B-cell regulator of IgH transcription; Bright; Dead ringer-like protein 1; E2F-binding protein 1
products gene name :
ARID3A
other gene names :
ARID3A; ARID3A; DRIL1; DRIL3; BRIGHT; E2FBP1
uniprot entry name :
ARI3A_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Western Blot (WB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [NCBI Entrez Gene Summary]
ncbi mol weight :
62,889 Da
ncbi pathways :
Direct P53 Effectors Pathway (137939)
ncbi summary :
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
uniprot summary :
Bright: a member of the ARID (AT-rich interaction domain) family of transcription factors. It was found by its homology to the Drosophila dead ringer protein, which is important for normal embryogenesis. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. Contributes to localized control of accessibility and therefore nonrandom gene use during V(D)J recombination. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleolus; lipid raft. Molecular Function: protein binding; protein homodimerization activity; chromatin binding. Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter