product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human ARNTL2
catalog :
MBS120053
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ARNTH6B5
reactivity :
human
application :
western blot, immunocytochemistry, flow cytometry, FACS
more info or order :
product information
catalog number :
MBS120053
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human ARNTL2
products short name :
ARNTL2
products name syn :
aryl hydrocarbon receptor nuclear translocator-like 2; CLIF; MOP9; BMAL2; PASD9
other names :
Homo sapiens aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2), transcript variant 1, mRNA; Aryl hydrocarbon receptor nuclear translocator-like protein 2; aryl hydrocarbon receptor nuclear translocator-like protein 2; CYCLE-like factor; PAS domain-containing protein 9; basic-helix-loop-helix-PAS protein MOP9; brain and muscle ARNT-like 2; class E basic helix-loop-helix protein 6; member of PAS protein 9; transcription factor BMAL2; aryl hydrocarbon receptor nuclear translocator-like 2; Basic-helix-loop-helix-PAS protein MOP9; Brain and muscle ARNT-like 2; CYCLE-like factor; CLIF; Class E basic helix-loop-helix protein 6; bHLHe6; Member of PAS protein 9; PAS domain-containing protein 9
products gene name :
ARNTL2
other gene names :
ARNTL2; ARNTL2; CLIF; MOP9; BMAL2; PASD9; bHLHe6
uniprot entry name :
BMAL2_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
ARNTH6B5
host :
Mouse
reactivity :
Human
sequence length :
7411
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
BMAL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. [UniProtKB Function]
ncbi gi num :
351721386
ncbi acc num :
NP_064568.3
ncbi gb acc num :
NM_020183
ncbi mol weight :
60,390 Da
ncbi pathways :
BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Circadian Clock Pathway (187173)
ncbi summary :
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
uniprot summary :
ARNTL2: ARNTL2-CLOCK heterodimers activate E-box element (5 - CACGTG-5 ) transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. 8 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 12p12.2-p11.2. Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus. Molecular Function: protein dimerization activity; signal transducer activity; transcription factor activity. Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock; positive regulation of circadian rhythm; signal transduction
size1 :
0.1 mg
price1 :
345 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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