antibody

Mouse monoclonal antibody Anti-Human SATB2

MBS120052

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

SATBA4B10

western blot, immunocytochemistry, immunoprecipitation

Antibody

Mouse monoclonal antibody Anti-Human SATB2

SATB2

SATB family member 2 (SATB2); FLJ21474; FLJ32076; KIAA1034; MGC119474;MGC119477

Homo sapiens SATB homeobox 2 (SATB2), transcript variant 2, mRNA; DNA-binding protein SATB2; DNA-binding protein SATB2; SATB family member 2; special AT-rich sequence-binding protein 2; SATB homeobox 2; Special AT-rich sequence-binding protein 2

SATB2

SATB2; SATB2; GLSS

SATB2_HUMAN

Monoclonal

IgG1

SATBA4B10

Mouse

Human

5306

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

May play an important role in palate formation. [UniProtKB Function]

289547592

NP_056080.1

NM_015265

69,137 Da

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]

SATB2: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI). A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis. A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22). Belongs to the CUT homeobox family. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 2q33. Cellular Component: nucleoplasm; transcription factor complex; nuclear matrix; cytoplasm; histone deacetylase complex. Molecular Function: protein binding; sequence-specific DNA binding; chromatin binding. Biological Process: chromatin remodeling; transcription, DNA-dependent; commitment of a neuronal cell to a specific type of neuron in the forebrain; cartilage development; neuron migration; positive regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; embryonic skeletal morphogenesis; osteoblast development. Disease: Glass Syndrome

0.1 mg

345 USD