Mouse monoclonal antibody Anti-Human BRF1 | MyBioSource MBS120050 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human BRF1

catalog :

MBS120050

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BRF1G2A8

reactivity :

human

application :

immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120050

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human BRF1

products short name :

BRF1

products name syn :

BRF1 homolog, subunit of RNA polymerase III? transcription initiation factor IIIB (S. cerevisiae) (BRF1); BRF; hBRF; GTF3B; TAF3C; TAF3B2; TF3B90;TAFIII90; TFIIIB90; MGC105048

other names :

Homo sapiens BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit (BRF1), transcript variant 1, mRNA; Transcription factor IIIB 90 kDa subunit; transcription factor IIIB 90 kDa subunit; B - related factor 1; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB; TATA box binding protein (TBP)-associated factor 3C; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2; TBP - associated factor, RNA polymerase III, 90kD; epididymis secretory sperm binding protein Li 76p; general transcription factor IIIB, 90kD subunit; BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit; B-related factor 1; BRF-1; hBRF; TAF3B2; TATA box-binding protein-associated factor, RNA polymerase III, subunit 2

products gene name :

BRF1

other gene names :

BRF1; BRF1; BRF; CFDS; hBRF; BRF-1; GTF3B; TAF3C; TAF3B2; TF3B90; TAFIII90; TFIIIB90; HEL-S-76p

uniprot entry name :

TF3B_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

BRF1G2A8

host :

Mouse

reactivity :

Human

sequence length :

3677

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized. [NCBI Entrez Gene Summary]

ncbi gi num :

338753403

ncbi acc num :

NP_001510.2

ncbi gb acc num :

NM_001519

ncbi mol weight :

47,978 Da

ncbi pathways :

Gene Expression Pathway (105937); Integrated Pancreatic Cancer Pathway (711360); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); RNA Polymerase III Abortive And Retractive Initiation Pathway (160949); RNA Polymerase III Transcription Pathway (106561); RNA Polymerase III Transcription Initiation Pathway (106562); RNA Polymerase III Transcription Initiation From Type 1 Promoter Pathway (106563); RNA Polymerase III Transcription Initiation From Type 2 Promoter Pathway (106564)

ncbi summary :

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]

uniprot summary :

GTF3B: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. Belongs to the TFIIB family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription initiation complex. Chromosomal Location of Human Ortholog: 14q. Cellular Component: nucleoplasm; transcription factor TFIIIB complex. Molecular Function: zinc ion binding; TATA-binding protein binding. Biological Process: transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase III promoter; tRNA transcription; regulation of transcription, DNA-dependent; gene expression; regulation of mRNA stability; rRNA transcription. Disease: Cerebellofaciodental Syndrome

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage