antibody

Mouse monoclonal antibody Anti-Human AATF

MBS120049

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

AATF2B6

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human AATF

AATF

apoptosis antagonizing transcription factor; CHE-1; DED; CHE1

Homo sapiens apoptosis antagonizing transcription factor, mRNA; Protein AATF; protein AATF; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; apoptosis antagonizing transcription factor; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1

AATF

AATF; AATF; DED; BFR2; CHE1; CHE-1

AATF_HUMAN

Monoclonal

IgG1

AATF2B6

Mouse

Human

2052

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [NCBI Entrez Gene Summary]

33875610

BC000591

63,133 Da

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); NRAGE Signals Death Through JNK Pathway (106444); Regulation Of Retinoblastoma Protein Pathway (137916); Signal Transduction Pathway (477114); Signalling By NGF Pathway (106439); P75 NTR Receptor-mediated Signalling Pathway (106441)

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family. Protein type: Transcription factor; RNA-binding; Nucleolus. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: Golgi apparatus; centrosome; focal adhesion; cytoplasm; nucleolus; nucleus. Molecular Function: leucine zipper domain binding; protein binding; transcription factor activity; tau protein binding. Biological Process: nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of amyloid precursor protein biosynthetic process; regulation of mitotic cell cycle; ribosome biogenesis and assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of superoxide release; cell adhesion; response to DNA damage stimulus; embryonic cleavage; negative regulation of apoptosis

0.1 mg

345 USD