antibody

Mouse monoclonal antibody Anti-Human TAF4B

MBS120045

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

TAFAD26A

ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Mouse monoclonal antibody Anti-Human TAF4B

TAF4B

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (TAF4B)

Transcription initiation factor TFIID subunit 4B; transcription initiation factor TFIID subunit 4B; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa; Transcription initiation factor TFIID 105 kDa subunit; TAF(II)105; TAFII-105; TAFII105

TAF4B

TAF4B; TAF4B; SPGF13; TAF2C2; TAFII105

TAF4B_HUMAN

Monoclonal

IgG1

TAFAD26A

Mouse

Human

618

100 ug/ml (1.0 ml)

ELISA (EIA), Immunocytochemistry (ICC)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM] [NCBI Entrez Gene Summary]

113427767

XM_290809

63,364 Da

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Disease Pathway (530764); Gene Expression Pathway (105937); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984); HIV Transcription Initiation Pathway (105998); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Huntington's Disease Pathway (83100)

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

TAF4B: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 18q11.2. Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleolus. Molecular Function: NF-kappaB binding; DNA binding; protein heterodimerization activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; oogenesis; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; gene expression; spermatogenesis. Disease: Spermatogenic Failure 13

0.1 mg

345 USD