antibody

Mouse monoclonal antibody Anti-Human STAT6

MBS120038

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

STAAD23A

western blot, ELISA, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

Antibody

Mouse monoclonal antibody Anti-Human STAT6

STAT6

signal transducer and activator of transcription 6, interleukin-4 induced (STAT6); STAT6B; STAT6C; D12S1644; IL-4-STAT

Homo sapiens signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), transcript variant 2, mRNA; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT; signal transducer and activator of transcription 6, interleukin-4 induced; IL-4 Stat

STAT6

STAT6; STAT6; STAT6B; STAT6C; D12S1644; IL-4-STAT

STAT6_HUMAN

Monoclonal

IgG1

STAAD23A

Mouse

Human

4031

100 ug/ml (1.0 ml)

ELISA (EIA), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [NCBI Entrez Gene Summary]

296010862

NP_003144.3

NM_003153

81,748 Da

Adipogenesis Pathway (198832); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Downstream Signal Transduction Pathway (106385); Hepatitis B Pathway (694606); IL-3 Signaling Pathway (198881); IL-4 Signaling Pathway (198760); IL12-mediated Signaling Events Pathway (137922); IL4-mediated Signaling Events Pathway (137933); Immune System Pathway (106386); Inflammatory Bowel Disease (IBD) Pathway (842771)

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: nucleoplasm; cytoplasm; nuclear chromatin; cytosol; lipid raft. Molecular Function: identical protein binding; signal transducer activity; protein binding; transcription factor activity; protein phosphatase binding. Biological Process: regulation of transcription from RNA polymerase II promoter; T-helper 1 cell lineage commitment; negative regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; mammary gland epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation

0.1 mg

345 USD