Mouse monoclonal antibody Anti-Human IRF3 | MyBioSource MBS120017 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human IRF3

catalog :

MBS120017

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IRF35I218

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS120017

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human IRF3

products short name :

IRF3

products name syn :

interferon regulatory factor 3

other names :

Homo sapiens interferon regulatory factor 3, mRNA; Interferon regulatory factor 3; interferon regulatory factor 3; interferon regulatory factor 3

products gene name :

IRF3

other gene names :

IRF3; IRF3

uniprot entry name :

IRF3_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

IRF35I218

host :

Mouse

reactivity :

Human

sequence length :

1716

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [NCBI Entrez Gene Summary]

ncbi gi num :

47940513

ncbi acc num :

BC071721

ncbi mol weight :

12,330 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (366171); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115)

ncbi summary :

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

uniprot summary :

IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; negative regulation of interferon-beta biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; negative regulation of defense response to virus by host; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; response to exogenous dsRNA; positive regulation of interferon type I production; positive regulation of interferon-beta production; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; innate immune response; interferon type I biosynthetic process; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production; defense response to virus; response to DNA damage stimulus; positive regulation of interferon-alpha production; positive regulation of cytokine secretion. Disease: Herpes Simplex Encephalitis, Susceptibility To, 7

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage