catalog number :
MBS120015
products full name :
Mouse monoclonal antibody Anti-Human DMTF1
products short name :
DMTF1
products name syn :
cyclin D binding myb-like transcription factor 1; DMP1; DMTF; hDMP1
other names :
Homo sapiens cyclin D binding myb-like transcription factor 1, mRNA; Cyclin-D-binding Myb-like transcription factor 1; cyclin-D-binding Myb-like transcription factor 1; cyclin D-binding Myb-like protein; cyclin-D-interacting Myb-like protein 1; hDMTF1; cyclin D binding myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; hDMP1
products gene name :
DMTF1
other gene names :
DMTF1; DMTF1; DMP1; DMTF; MRUL; hDMP1
uniprot entry name :
DMTF1_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
ncbi mol weight :
74,878 Da
ncbi pathways :
Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway 169349
ncbi summary :
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]