antibody

Mouse monoclonal antibody Anti-Human POU2F1

MBS120010

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

POU5I097

western blot, immunocytochemistry

Antibody

Mouse monoclonal antibody Anti-Human POU2F1

POU2F1

POU domain, class 2, transcription factor 1; OCT1; OTF1

Homo sapiens POU class 2 homeobox 1, mRNA; POU domain, class 2, transcription factor 1; POU domain, class 2, transcription factor 1; NF-A1; OTF-1; Octamer-binding transcription factor-1; oct-1; octamer-binding protein 1; octamer-binding transcription factor 1; POU class 2 homeobox 1; NF-A1; Octamer-binding protein 1; Oct-1; Octamer-binding transcription factor 1; OTF-1

POU2F1

POU2F1; POU2F1; OCT1; OTF1; oct-1B

PO2F1_HUMAN

Monoclonal

IgG1

POU5I097

Mouse

Human

2689

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). [UniProtKB Function]

30354476

BC052274

72,082 Da

ATF-2 Transcription Factor Network Pathway (138006); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); FOXA1 Transcription Factor Network Pathway (137979); Gene Expression Pathway (105937); Glucocorticoid Receptor Regulatory Network Pathway (138014); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); RNA Polymerase III Abortive And Retractive Initiation Pathway (160949); RNA Polymerase III Transcription Pathway (106561); RNA Polymerase III Transcription Initiation Pathway (106562)

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

Oct1: a ubiquitous transcription factor that binds to the octamer motif (5 -ATTTGCAT-3 ) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. Phosphorylation apparently inhibits its interaction with DNA. Four splice variant isoforms have been described. Isoform 2 is lymphocyte specific. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 1q24.2. Cellular Component: nucleoplasm; transcription factor complex; intracellular membrane-bound organelle; nucleus. Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription, DNA-dependent; olfactory placode formation

0.1 mg

345 USD