antibody

Mouse monoclonal antibody Anti-Human CBFA2T2

MBS120008

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

CBF5I134

western blot, immunocytochemistry, flow cytometry, FACS

Antibody

Mouse monoclonal antibody Anti-Human CBFA2T2

CBFA2T2

core-binding factor,alpha subunit 2; MTGR1; EHT; ZMYND3

Homo sapiens core-binding factor, runt domain, alpha subunit 2; translocated to, 2, mRNA; Protein CBFA2T2; protein CBFA2T2; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; myeloid translocation gene-related protein 1; myeloid translocation-related protein 1; core-binding factor, runt domain, alpha subunit 2; translocated to, 2; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85

CBFA2T2

CBFA2T2; CBFA2T2; EHT; p85; MTGR1; ZMYND3

MTG8R_HUMAN

Monoclonal

IgG1

CBF5I134

Mouse

Human

5595

100 ug/ml (1.0 ml)

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB), Flow Cytometry (FC/FACS)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [NCBI Entrez Gene Summary]

34193058

BC040344

65,878 Da

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

CBFA2T2: May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Belongs to the CBFA2T family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 20q11. Cellular Component: nucleus. Molecular Function: protein binding; metal ion binding; transcription corepressor activity; transcription factor activity. Biological Process: epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

0.1 mg

345 USD