antibody

Mouse monoclonal antibody Anti-Human ASH1L

MBS120006

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

ASH5H03

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human ASH1L

ASH1L

ash1 (absent, small, or homeotic)-like (Drosophila)? (ASH1L); ASH1; ASH1L1; huASH1; FLJ10504; KIAA1420

Homo sapiens ash1 (absent, small, or homeotic)-like (Drosophila) (ASH1L), mRNA; Histone-lysine N-methyltransferase ASH1L; histone-lysine N-methyltransferase ASH1L; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N-methyltransferase 2H; probable histone-lysine N-methyltransferase ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila); ASH1-like protein; huASH1; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H

ASH1L

ASH1L; ASH1L; ASH1; KMT2H; ASH1L1

ASH1L_HUMAN

Monoclonal

IgG1

ASH5H03

Mouse

Human

11784

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [NCBI Entrez Gene Summary]

110349787

NP_060959.2

NM_018489

332,211 Da

Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320); Tight Junction Pathway (83071); Tight Junction Pathway (482)

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

ASH1L: a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Protein type: Methyltransferase; Methyltransferase, protein lysine; Cell adhesion; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: nucleoplasm; Golgi apparatus; tight junction; cytoplasm; chromosome; nucleus. Molecular Function: DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); chromatin binding. Biological Process: transcription from RNA polymerase II promoter; cell-cell signaling; interleukin-6 production; negative regulation of MAPKKK cascade; histone H3-K4 methylation; negative regulation of acute inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA packaging

0.1 mg

345 USD