product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human YARS
catalog :
MBS120005
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
YAR5H08
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS120005
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human YARS
products short name :
YARS
products name syn :
tyrosyl-tRNA synthetase (YARS); YRS; YTS; TYRRS; CMTDIC
other names :
Homo sapiens tyrosyl-tRNA synthetase (YARS), mRNA; Tyrosine--tRNA ligase, cytoplasmic; tyrosine--tRNA ligase, cytoplasmic; tyrosine tRNA ligase 1, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic; tyrosyl-tRNA synthetase; Tyrosyl-tRNA synthetase; TyrRS
products gene name :
YARS
other gene names :
YARS; YARS; YRS; YTS; TYRRS; CMTDIC
uniprot entry name :
SYYC_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
YAR5H08
host :
Mouse
reactivity :
Human
sequence length :
3117
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [NCBI Entrez Gene Summary]
ncbi gi num :
156071485
ncbi acc num :
NP_003671.1
ncbi gb acc num :
NM_003680
ncbi mol weight :
59,143 Da
ncbi pathways :
Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); TRNA Aminoacylation Pathway (105980)
ncbi summary :
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
uniprot summary :
YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family. Protein type: EC 6.1.1.1; Ligase. Chromosomal Location of Human Ortholog: 1p35.1. Cellular Component: extracellular space; cytoplasm; nucleus; cytosol. Molecular Function: signal transducer activity; tyrosine-tRNA ligase activity; ATP binding; interleukin-8 receptor binding; isoleucine-tRNA ligase activity; tRNA binding. Biological Process: tyrosyl-tRNA aminoacylation; isoleucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; apoptosis; gene expression; signal transduction. Disease: Charcot-marie-tooth Disease, Dominant Intermediate C
size1 :
0.1 mg
price1 :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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