antibody

Mouse monoclonal antibody Anti-Human TFAP2C

MBS120001

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

AP25H01

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human TFAP2C

TFAP2C

transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) (TFAP2C); ERF1; TFAP2G; hAP-2g; AP2-GAMMA

Homo sapiens transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) (TFAP2C), mRNA; Transcription factor AP-2 gamma; transcription factor AP-2 gamma; activating enhancer-binding protein 2 gamma; estrogen receptor factor 1; transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma); transcription factor ERF-1; transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1

TFAP2C

TFAP2C; TFAP2C; ERF1; TFAP2G; hAP-2g; AP2-GAMMA

AP2C_HUMAN

Monoclonal

IgG1

AP25H01

Mouse

Human

2895

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [NCBI Entrez Gene Summary]

39812473

NP_003213.1

NM_003222

31,010 Da

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5 -GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family. Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 20q13.2. Cellular Component: nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; male gonad development; sebaceous gland development; germ-line stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; regulation of cell proliferation; trophectodermal cell differentiation; regulation of transcription from RNA polymerase II promoter; hair follicle development; cell-cell signaling; positive regulation of transcription from RNA polymerase II promoter; forebrain neuron fate commitment; cerebral cortex development; regulation of epidermis development

0.1 mg

345 USD