catalog number :
MBS1192601
products type :
Recombinant Protein
products full name :
Recombinant Human CLIP-associating protein 2 (CLASP2), partial
products short name :
CLIP-associating protein 2 (CLASP2), partial
products name syn :
CLIP-associating protein 2; Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
other names :
CLIP-associating protein 2 isoform 2; CLIP-associating protein 2; CLIP-associating protein 2; protein Orbit homolog 2; multiple asters (Mast)-like homolog 2; cytoplasmic linker-associated protein 2; cytoplasmic linker associated protein 2; Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
products gene name :
CLASP2
products gene name syn :
CLASP2; KIAA0627
other gene names :
CLASP2; CLASP2; KIAA0627; hOrbit2
uniprot entry name :
CLAP2_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
ncbi acc num :
NP_001193973.1
ncbi gb acc num :
NM_001207044.1
ncbi mol weight :
46,585 Da
ncbi pathways :
Axon Guidance Pathway (824307); Axon Guidance Pathway (105688); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Developmental Biology Pathway (824306); Developmental Biology Pathway (477129); M Phase Pathway (105812); Mitotic Anaphase Pathway (105818); Mitotic Metaphase And Anaphase Pathway (730317); Mitotic Prometaphase Pathway (105815)
uniprot summary :
CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 3p22.3. Cellular Component: kinetochore microtubule; Golgi apparatus; microtubule; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; microtubule organizing center; cell cortex; trans-Golgi network; cytosol. Molecular Function: microtubule plus-end binding; protein binding; galactoside 2-alpha-L-fucosyltransferase activity. Biological Process: mitosis; regulation of microtubule-based process; microtubule organizing center organization and biogenesis; axon guidance; negative regulation of microtubule depolymerization; cell division; establishment and/or maintenance of cell polarity; mitotic cell cycle; microtubule nucleation; regulation of microtubule polymerization or depolymerization
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)