catalog number :
MBS1187104
products type :
Recombinant Protein
products full name :
Recombinant Macaca mulatta (Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial
products short name :
(Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial
products name syn :
Recombinant (Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial; NACHT, LRR and PYD domains-containing protein 3
other names :
NACHT, LRR and PYD domains-containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NLR family pyrin domain containing 3
products gene name syn :
NLRP3
other gene names :
NLRP3; NLRP3
uniprot entry name :
NALP3_MACMU
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Macaca mulatta (Rhesus macaque)
ncbi acc num :
NP_001107823.1
ncbi gb acc num :
NM_001114351.1
ncbi mol weight :
118,192 Da
ncbi pathways :
Influenza A Pathway (217176); Influenza A Pathway (217150); NOD-like Receptor Signaling Pathway (122199); NOD-like Receptor Signaling Pathway (122131); Pertussis Pathway (218113); Pertussis Pathway (218099)
uniprot summary :
Function: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18 . By similarity. Subunit structure: Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18 . By similarity. Subcellular location: Cytoplasm . By similarity. Tissue specificity: Highly expressed in oocyte, testis, spleen, thymus and kidney. Ref.1. Sequence similarities: Belongs to the NLRP family.Contains 1 DAPIN domain.Contains 9 LRR (leucine-rich) repeats.Contains 1 NACHT domain.