catalog number :
MBS1185591
products type :
Recombinant Protein
products full name :
Recombinant Mouse Dihydropyrimidinase-related protein 2 (Dpysl2)
products short name :
Dihydropyrimidinase-related protein 2 (Dpysl2)
products name syn :
Dihydropyrimidinase-related protein 2; DRP-2; Unc-33-like phosphoprotein 2; ULIP-2
other names :
dihydropyrimidinase-related protein 2; Dihydropyrimidinase-related protein 2; dihydropyrimidinase-related protein 2; DRP-2; ULIP-2; unc-33-like phosphoprotein 2; collapsin response mediator protein 2; dihydropyrimidinase-like 2; Unc-33-like phosphoprotein 2; ULIP-2
products gene name :
Dpysl2
products gene name syn :
Dpysl2; Crmp2; Ulip2
other gene names :
Dpysl2; Dpysl2; DRP2; Crmp2; Ulip2; TOAD-64; AI851130; Musunc33; Crmp2; Ulip2; DRP-2; ULIP-2
uniprot entry name :
DPYL2_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-572
sequence :
MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ITEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDSQ IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRSI TIANQTNCPL YVTKVMSKSA AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR ISVGSDADLV IWDPDSVKTI SAKTHNSALE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mus musculus (Mouse)
products description :
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
ncbi acc num :
NP_034085.2
ncbi gb acc num :
NM_009955.3
ncbi mol weight :
62,278 Da
ncbi pathways :
Axon Guidance Pathway (83262); Axon Guidance Pathway (476); Axon Guidance Pathway (970585); CRMPs In Sema3A Signaling Pathway (1000764); Developmental Biology Pathway (970813); L1CAM Interactions Pathway (1000776); PluriNetWork Pathway (198307); Recycling Pathway Of L1 (1000777); Semaphorin Interactions Pathway (1000758)
uniprot summary :
CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Protein type: Motility/polarity/chemotaxis; Microtubule-binding. Cellular Component: microtubule; neuron projection; protein complex; mitochondrion; dendrite; terminal button; cytosol; growth cone; cytoskeleton; cell soma; membrane; axon; cytoplasm; myelin sheath. Molecular Function: protein binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; protein kinase binding. Biological Process: nervous system development; regulation of neuron differentiation; multicellular organismal development; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; cell differentiation
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)