Recombinant Human ATP-binding cassette sub-family A member 1 (ABCA1), partial | MyBioSource MBS1176942 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human ATP-binding cassette sub-family A member 1 (ABCA1), partial

catalog :

MBS1176942

quantity :

1 mg (E-Coli)

price :

1375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1176942

products type :

Recombinant Protein

products full name :

Recombinant Human ATP-binding cassette sub-family A member 1 (ABCA1), partial

products short name :

ATP-binding cassette sub-family A member 1 (ABCA1), partial

products name syn :

Recombinant ATP-binding cassette sub-family A member 1 (ABCA1), partial; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1 Cholesterol efflux regulatory protein

other names :

ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; membrane-bound; ATP-binding cassette transporter A1; cholesterol efflux regulatory protein; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein

products gene name syn :

ABCA1; ABC1, CERP

other gene names :

ABCA1; ABCA1; TGD; ABC1; CERP; ABC-1; HDLDT1; ABC1; CERP; ABC-1

uniprot entry name :

ABCA1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

21536376

ncbi acc num :

NP_005493.2

ncbi gb acc num :

NM_005502.3

uniprot acc num :

O95477

ncbi mol weight :

254,302 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Folate Metabolism Pathway (198833); HDL-mediated Lipid Transport Pathway (106158); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies. Protein type: Membrane protein, multi-pass; Vesicle; Transporter, ABC family; Membrane protein, integral; Transporter. Chromosomal Location of Human Ortholog: 9q31.1. Cellular Component: Golgi apparatus; endocytic vesicle; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft. Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; cholesterol binding; apolipoprotein binding; ATPase binding; small GTPase binding; apolipoprotein A-I binding; protein binding; syntaxin binding; phospholipid transporter activity; cholesterol transporter activity; anion transmembrane transporter activity; phospholipid binding; ATP binding; receptor binding. Biological Process: response to drug; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; cholesterol efflux; lipoprotein metabolic process; intracellular cholesterol transport; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; platelet dense granule organization and biogenesis; phospholipid efflux; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; response to nutrient; peptide secretion; phospholipid homeostasis. Disease: Hypoalphalipoproteinemia, Primary; Tangier Disease; Hypercholesterolemia, Familial

size1 :

1 mg (E-Coli)

price1 :

1375 USD

size2 :

1 mg (Yeast)

price2 :

1835

more info or order :

MyBioSource product webpage