Recombinant Human Menin (MEN1) | MyBioSource MBS1167332 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Menin (MEN1)

catalog :

MBS1167332

quantity :

0.5 mg (E-Coli)

price :

1410 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1167332

products type :

Recombinant Protein

products full name :

Recombinant Human Menin (MEN1)

products short name :

Menin (MEN1)

products name syn :

Menin

other names :

menin isoform 1; Menin; menin; multiple endocrine neoplasia I

products gene name :

MEN1

products gene name syn :

MEN1; SCG2

other gene names :

MEN1; MEN1; MEAI; SCG2; SCG2

uniprot entry name :

MEN1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-615

sequence length :

615

sequence :

MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA QVPAPTASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP SDYTLSFLKR QRKGL

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

ncbi gi num :

18860839

ncbi acc num :

NP_000235.2

ncbi gb acc num :

NM_000244.3

uniprot acc num :

O00255

ncbi mol weight :

65kD

ncbi pathways :

Cell Cycle Pathway (198811); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); SMAD2/SMAD3:SMAD4 Heterotrimer Regulates Transcription Pathway (645265); Signal Transduction Pathway (477114); Signaling By TGF-beta Receptor Complex Pathway (106504); Transcriptional Activity Of SMAD2/SMAD3:SMAD4 Heterotrimer Pathway (645264); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

uniprot summary :

MEN1: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at Ser-5 , but not with the unphosphorylated, nor Ser-2 phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: nucleoplasm; histone methyltransferase complex; protein complex; nuclear matrix; cytoplasm; nucleus; chromatin; cytosol; cleavage furrow. Molecular Function: protein binding, bridging; Y-form DNA binding; protein binding; four-way junction DNA binding; sequence-specific DNA binding; double-stranded DNA binding; protein N-terminus binding; chromatin binding; histone-lysine N-methyltransferase activity. Biological Process: negative regulation of JNK cascade; maternal process involved in pregnancy; positive regulation of protein binding; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; response to gamma radiation; negative regulation of osteoblast differentiation; hemopoiesis; cell cycle arrest; leukocyte homeostasis; response to UV; transcription initiation from RNA polymerase II promoter; positive regulation of histone methylation; transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of cyclin-dependent protein kinase activity; MAPKKK cascade; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of organ growth; DNA repair; regulation of activin receptor signaling pathway; embryonic skeletal morphogenesis; osteoblast development; chromatin remodeling; positive regulation of osteoblast differentiation; negative regulation of telomerase activity; positive regulation of cell division; positive regulation of transcription from RNA polymerase II promoter; gene expression; brain development; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; osteoblast fate commitment. Disease: Multiple Endocrine Neoplasia, Type I

size1 :

0.5 mg (E-Coli)

price1 :

1410 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1410

size3 :

0.5 mg (Yeast)

price3 :

1640

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1640

size5 :

1 mg (E-Coli)

price5 :

2380

more info or order :

MyBioSource product webpage