Recombinant Rat Haptoglobin (Hp) | MyBioSource MBS1141822 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Rat Haptoglobin (Hp)

catalog :

MBS1141822

quantity :

0.5 mg (E-Coli)

price :

1090 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1141822

products type :

Recombinant Protein

products full name :

Recombinant Rat Haptoglobin (Hp)

products short name :

Haptoglobin (Hp)

products name syn :

Haptoglobin; Liver regeneration-related protein LRRG173Cleaved into the following 2 chains:; 1. Haptoglobin alpha chain; 2. Haptoglobin beta chain

other names :

haptoglobin; Haptoglobin; haptoglobin; zonulin; liver regeneration-related protein LRRG173; haptoglobin; Liver regeneration-related protein LRRG173; ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain

products gene name :

products gene name syn :

Hp; Ba1-647

other gene names :

Hp; Hp; Ba1-647; Ba1-647

uniprot entry name :

HPT_RAT

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

19-347

sequence length :

329

sequence :

VE LGNDATDIED DSCPKPPEIA NGYVEHLVRY RCRQFYKLQT EGDGIYTLNS EKQWVNPAAG DKLPKCEAVC GKPKHPVDQV QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAQNLFLNHS ENATAKDIAP TLTLYVGKNQ LVEIEKVVLH PERSVVDIGL IKLKQKVLVT EKVMPICLPS KDYVAPGRMG YVSGWGRNVN FRFTERLKYV MLPVADQEKC ELHYEKSTVP EKKGAVSPVG VQPILNKHTF CAGLTKYEED TCYGDAGSAF AVHDTEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Rattus norvegicus (Rat)

products description :

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway .

ncbi gi num :

60097941

ncbi acc num :

NP_036714.2

ncbi gb acc num :

NM_012582.2

uniprot acc num :

P06866

ncbi mol weight :

42,475 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1010669); Scavenging Of Heme From Plasma Pathway (1010670)

ncbi summary :

may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]

uniprot summary :

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Endoplasmic reticulum; Protease; Enzyme, misc.; Secreted; Secreted, signal peptide. Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum. Molecular Function: antioxidant activity; protein homodimerization activity; hemoglobin binding; catalytic activity. Biological Process: response to drug; organ regeneration; immune system process; metabolic process; response to glucocorticoid stimulus; response to lipopolysaccharide; liver development; response to organic cyclic substance; response to L-ascorbic acid; response to organic substance; response to magnesium ion; response to hydrogen peroxide; response to heat; defense response to bacterium; response to lead ion; negative regulation of oxidoreductase activity; response to hypoxia; acute-phase response; spermatogenesis; response to electrical stimulus; response to cobalamin; acute inflammatory response; response to X-ray

size1 :

0.5 mg (E-Coli)

price1 :

1090 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1090

size3 :

0.5 mg (Yeast)

price3 :

1320

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1320

size5 :

1 mg (E-Coli)

price5 :

1715

more info or order :

MyBioSource product webpage