protein

Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 10 (Adam10)

MBS1127986

0.5 mg (E-Coli)

1455 USD

Recombinant Protein

Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 10 (Adam10)

Disintegrin and metalloproteinase domain-containing protein 10 (Adam10)

Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; EC=3.4.24.81; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen=; CD156c

disintegrin and metalloproteinase domain-containing protein 10; Disintegrin and metalloproteinase domain-containing protein 10; disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metallopeptidase domain 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c

Adam10

Adam10; Kuz; Madm

Adam10; Adam10; kuz; MADM; kuzbanian; 1700031C13Rik; Kuz; Madm; ADAM 10

ADA10_MOUSE

E Coli or Yeast or Baculovirus or Mammalian Cell

20-673

654

Q YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL LLDFHAHGRQ FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI DGRFEGFIKT RGGTFYIEPA ERYIKDRILP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE RMRKYQMTGV EEGARAHPEK HAASSGPELL RKKRTTLAER NTCQLYIQTD HLFFKYYGTR EAVIAQISSH VKAIDTIYQT TDFSGIRNIS FMVKRIRINT TSDEKDPTNP FRFPNIGVEK FLELNSEQNH DDYCLAYVFT DRDFDDGVLG LAWVGAPSGS SGGICEKSKL YSDGKKKSLN TGIITVQNYG SHVPPKVSHI TFAHEVGHNF GSPHDSGTEC TPGESKNLGQ KENGNYIMYA RATSGDKLNN NKFSLCSIRN ISQVLEKKRN NCFVESGQPI CGNGMVEQGE ECDCGYSDQC KDDCCFDANQ PEGKKCKLKP GKQCSPSQGP CCTAQCAFKS KSEKCRDDSD CAKEGICNGF TALCPASDPK PNFTDCNRHT QVCINGQCAG SICEKYDLEE CTCASSDGKD DKELCHVCCM KKMAPSTCAS TGSLQWSKQF SGRTITLQPG SPCNDFRGYC DVFMRCRLVD ADGPLARLKK AIFSPQLYEN IAE

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Mus musculus (Mouse)

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface By similarity. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys- -Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

150378458

NP_031425.2

NM_007399.3

O35598

83,968 Da

Activated NOTCH1 Transmits Signal To The Nucleus Pathway (926321); Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Collagen Degradation Pathway (927076); Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway (926324); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (926328); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (926326); Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway (926319); Degradation Of The Extracellular Matrix Pathway (927074); Delta-Notch Signaling Pathway (198316)

ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at 76-Ala- -Val-77 to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. Protein type: Cell adhesion; EC 3.4.24.81; Vesicle; Motility/polarity/chemotaxis; Protease; Membrane protein, integral; Cell surface. Cellular Component: Golgi apparatus; cell surface; focal adhesion; intracellular membrane-bound organelle; cell; postsynaptic density; integral to membrane; trans-Golgi network; membrane; cytoplasm; Golgi-associated vesicle; intracellular; nucleus. Molecular Function: peptidase activity; protein binding; protein homodimerization activity; hydrolase activity; zinc ion binding; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; endopeptidase activity; SH2 domain binding; SH3 domain binding; protein kinase binding. Biological Process: Notch signaling pathway; in utero embryonic development; constitutive protein ectodomain proteolysis; membrane protein ectodomain proteolysis; Notch receptor processing; nucleocytoplasmic transport; negative regulation of cell adhesion; proteolysis; positive regulation of cell growth; protein amino acid phosphorylation; PMA-inducible membrane protein ectodomain proteolysis; monocyte activation; positive regulation of cell proliferation; positive regulation of cell migration

0.5 mg (E-Coli)

1455 USD

0.05 mg (Baculovirus)

1455

0.5 mg (Yeast)

1680

0.05 mg (Mammalian-Cell)

1680

1 mg (E-Coli)

2470