protein

Recombinant Mouse Polycystin-2 (Pkd2)

MBS1127233

1 mg (E-Coli)

1170 USD

Recombinant Protein

Recombinant Mouse Polycystin-2 (Pkd2)

Polycystin-2 (Pkd2)

Recombinant Polycystin-2 (Pkd2); Polycystin-2; Polycystic kidney disease 2 protein homolog

polycystin-2; Polycystin-2; polycystin-2; polycystin 2; polycystic kidney disease 2 protein homolog; polycystic kidney disease 2; Polycystic kidney disease 2 protein homolog

Pkd2

Pkd2; Pkd2; PC2; TRPP2; C030034P18Rik

PKD2_MOUSE

E Coli or Yeast or Baculovirus or Mammalian Cell

273-358

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Mus musculus (Mouse)

164519057

NP_032887.3

NM_008861.3

O35245

108,982 Da

PKD2: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Belongs to the polycystin family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, cation; Membrane protein, multi-pass; Membrane protein, integral. Cellular Component: endoplasmic reticulum membrane; nonmotile primary cilium; endoplasmic reticulum; integral to plasma membrane; integral to membrane; intercellular junction; cytosol; cilium; filamentous actin; cell projection; membrane; lamellipodium; cytoplasm; plasma membrane; basal plasma membrane; motile primary cilium; basal cortex. Molecular Function: voltage-gated cation channel activity; actinin binding; identical protein binding; protein homodimerization activity; channel activity; metal ion binding; calcium channel activity; phosphoprotein binding; voltage-gated ion channel activity; calcium ion binding; alpha-actinin binding; muscle alpha-actinin binding; ATPase binding; voltage-gated calcium channel activity; calcium-induced calcium release activity; protein binding; potassium channel activity; cytoskeletal protein binding; voltage-gated sodium channel activity; HLH domain binding; receptor binding. Biological Process: embryonic placenta development; positive regulation of inositol-1,4,5-triphosphate receptor activity; cytoplasmic sequestering of transcription factor; positive regulation of nitric oxide biosynthetic process; regulation of cAMP metabolic process; heart development; detection of mechanical stimulus; JAK-STAT cascade; liver development; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; regulation of cell proliferation; cellular calcium ion homeostasis; elevation of cytosolic calcium ion concentration; transport; calcium ion transport; release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; ion transport; heart looping; cell cycle arrest; determination of left/right symmetry; kidney development; transmembrane transport

1 mg (E-Coli)

1170 USD